{"product_id":"firming-cream-dmae-coq10","title":"Firming Cream with DMAE \u0026 CoQ10","description":"\u003cp\u003eUse for the look of firmer, more defined skin on the neck, jawline, and décolletage. Built around DMAE, with antioxidant support from CoQ10 and moisture from hyaluronic acid — without a heavy finish.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eThe ingredients:\u003c\/strong\u003e Purified Water, DMAE, Hyaluronic Acid, CoQ10, Aloe Vera Extract, Vitamin E Oil, Avocado Oil, Rheosol, Almond Oil, Phenonip, Rosemary Extract.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eCompare to:\u003c\/strong\u003e Perricone MD High Potency Classics (4oz) — $119.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eWhy we use these ingredients\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eDMAE is one of the few cosmetic ingredients with a placebo-controlled study behind it (Grossman 2005), looking at the appearance of firmness around the forehead and eyes.\u003c\/li\u003e\n\u003cli\u003eCoQ10 is an antioxidant with its own research on the look of fine lines.\u003c\/li\u003e\n\u003cli\u003eHyaluronic acid draws in moisture and gives the formula a smooth, light feel.\u003c\/li\u003e\n\u003cli\u003eA less-crowded corner of the research: where most actives aim at fine lines, DMAE has been studied for the look of firmness specifically.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eRead the research\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15675889\/\"\u003eGrossman 2005, Am J Clin Dermatol — 3% DMAE, placebo-controlled, 16 weeks\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/www.jaad.org\/article\/S0190-9622(03)03633-8\/fulltext\"\u003eUhoda 2002, JAAD — DMAE split-face study\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4123624\/\"\u003eDMAE and amino acids — PMC mechanistic review\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25208826\/\"\u003eKnott 2015, BioFactors — topical CoQ10, double-blind study\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16757771\/\"\u003eBlatt 2005, BioFactors — CoQ10 ingredient research\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAbout this formula\u003c\/strong\u003e\u003cbr\u003eDMAE is one of the more quietly interesting ingredients in cosmetic skincare. It has a placebo-controlled study behind it — Grossman 2005, 3% DMAE over 16 weeks — looking at the appearance of forehead lines, the eye area, and firmness. That is rarer than marketing tends to suggest; most ingredients marketed for firmness have no controlled data at all. The proposed mechanism involves acetylcholine signaling at the skin–muscle interface and is still being worked out in the literature.\u003c\/p\u003e\u003cp\u003eWe pair DMAE with hyaluronic acid for moisture and Coenzyme Q10, an antioxidant with its own research on the look of fine lines. It is made with the neck, jawline, and décolletage in mind — the areas that tend to lose definition first.\u003c\/p\u003e\u003cp\u003eA note on expectations: DMAE is about the look of firmness, not fine lines. It does not do what retinol does, and does not try to. It is a focused tool for one thing.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eWhat's not in it:\u003c\/strong\u003e No synthetic fragrance, no essential oils.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eHow to use:\u003c\/strong\u003e Apply once or twice daily to the face, neck, and jawline.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eMade in USA · 2 oz.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Sorrel \u0026 Co","offers":[{"title":"Default Title","offer_id":48116437745918,"sku":"BSMIT-SFC-1C14","price":72.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0803\/4379\/3918\/files\/sorrel-firming-cream-dmae-coq10-1.jpg?v=1780156952","url":"https:\/\/sorrel.skin\/products\/firming-cream-dmae-coq10","provider":"Sorrel \u0026 Co","version":"1.0","type":"link"}